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Canadian Association of University Teachers
Association canadienne des professeures et professeurs d'université

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Research Associate (Kelleher Laboratory), Gastroenterology Division

University of British Columbia

The Kelleher laboratory is seeking a research associate to join, lead and support a dynamic and newly established research team at the Life Science Institute at the University of British Columbia. The Kelleher laboratory investigates the roles of inflammation in gastrointestinal disease pathogenesis with a specific focus in esophageal cancers. Cancers of the esophagus are associated with one of the poorest overall survival percentages of all cancer types and occurs as either a squamo- or adeno-carcinoma. Pre-cancerous lesions such as Barrett's esophagus, and associated dysplasia, are common precursors in many adenocarcinomas and result from an altered, and genomically unstable, intestine-like differentiation programme (Duggan et al 2015 for example). The Kelleher lab has recently published a number of studies demonstrating the pathways connecting gastro-esophageal reflux disease with GATA family transcription factors supporting differentiation (Duggan, Kelleher et al 2015), inducing pro-proliferative secreted inflammatory cytokines (Duggan, Kelleher 2018) and inducing pro-metastatic cellular transitions (Phipps, Kelleher, Duggan et al 2020) during esophageal oncogenesis. Thus we, and others, suggest a clear role for inflammation in supporting disease states.

In this position, the candidates will utilise a novel organoid/regenerative medicine-based model of precancerous esophageal lesions, regenerative medicine, pathological and single cell genomic strategies to dissect the relationship between stem cell differentiation, somatic variation and inflammation in the gastro-intestinal tract. This project will be supported by the combined strengths of the division of gastroenterology at UBC, BC cancer and the Michael Smith Genome Sciences Centre.

This position is an ideal opportunity for a trained post doctoral fellow with significant experiences in esophageal pathogenesis, organoid development, stem and cancer cell biology and genomics; in addition to experience in research program supervision, research funding and supervision of graduate undergraduate and post doctoral students fellows.

Prerequisite skills include: Stem cell culture, organoid disease modelling, RNAseq and scRNAseq genomic analyses, siRNA/shRNA/CRISPr gene editing/silencing of gene expression, molecular immunology, molecular gastroenterology, pathological studies using organoid generation and manipulation. We expect the candidates to have proven skills, through a level appropriate publication record, and that the candidates have some experience in laboratory based teaching. Advantageous skills include:-. Experience in Bioinformatic analyses/computational biology with published contributions, experience will high single molecule cell biology and imaging, animal modelling of disease.

Expected start date is October 2020.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.