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Association canadienne des professeures et professeurs d'université

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Research Associate, Physiology & Pharmacology

University of Calgary

The Department of Physiology & Pharmacology in the Cumming School of Medicine invites applications for a Research Associate. This Full-time Fixed Term position is for approximately 3 years (based on length of grant funding), with the possibility of extension.

This position reports to the Principal Investigator to investigate the roles of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in the pathogenesis of Alzheimer's disease and dementia. Specifically, the Research Associate will investigate:

1. The role of ryanodine receptor type 2 (RyR2) in neuronal excitability, learning and memory, and neuronal cell loss;
2. The role of RyR2 in surface expression and trafficking of ion channels;
3. The role of inositol 1,4,5-trisphosphate receptors in neuronal excitability, learning and memory, and neuronal cell loss

The Research Associate’s primary purpose is to be responsible for the management, maintenance, or control of a specialized area. They are to perform research to understand the roles of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in the pathogenesis of neuronal disorders.

Summary of Key Responsibilities (job functions include but are not limited to):

• Perform 2-photon hippocampal calcium imaging in vivo
• Perform immunoblotting and immunostaining
• Perform patch-clamp recordings on brain slices, isolated neurons, isolated cardiac cells, and HEK293 cells
• Perform confocal calcium imaging on isolated cells, heart slices, and brain slices
• Perform a variety of mouse behavioral tests
• Perform data analyses and prepare figures and manuscripts
• Assists in performing more complex tasks, such as:

o perform craniotomy with mice
o remove certain parts of the cerebral cortex to exposure the dorsal hippocampus for in vivo imaging and at the same time, maintain the anesthesia of the animal during the whole procedure
o animal surgery
o post operative care
• Under limited supervision and direction, develop and implement original experiments within the guidelines of the research
• Conduct literature review, surveys, data analysis and interpretation, laboratory experiments and other research for use in scholarly publications
• Use of various biological samples
• Recommend change to processes or procedures
• Direct and demonstrable research experience in the subject matter of the research project is essential
• Perform detailed design, documentation, and implementation of moderately complex technological systems
• Trains and supervises other staff, students, and Faculty in the operation of equipment and laboratory protocols
• Assist with plans and designs for specialized applications to meet the needs of operations, research, and services
• Participate in the design and development of precision equipment and processes

Qualifications / Requirements:
• PhD degree in Biophysics or Neuroscience required
• 7-10 years of technical experience, with a minimum of 4-5 years of post-doctoral experience in neurodegenerative diseases, for example, Alzheimer's Disease, Parkinson Disease, Huntington Disease, et al
• Ability to perform detailed design, documentation, and implementation of moderately complex technological systems
• Ability to perform surgical procedures such as craniotomy with mice for in vivo imaging.
• Ability to provide technical support for other team members through advice on technical lab issues
• Interact with other members of the team and undertake literature reviews
• Extensive knowledge of theory and practical application of technical procedures and techniques
• Must be open to learning and development, and be willing to accept new challenges and assignments.
• Understanding of safety codes and standards related to specialization
• Operate and maintain complex technical equipment
• Experience with various biological samples (eg. blood, tissues, urine, etc)
• Demonstrated leadership, communication, organization, problem solving, and interpersonal skills
• Advanced skills in Microsoft Office Suite, Internet skills
• Knowledge of University core business systems is desirable
• WHIMS Certification

Application Deadline: September 30, 2019

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority. In this connection, at the time of your application, please answer the following question: are you a Canadian citizen or a permanent resident of Canada? (Yes/No).

We would like to thank all applicants in advance for submitting their resumes. Please note, only those candidates chosen to continue on through the selection process will be contacted.
To Apply, please visit the University of Calgary’s career opportunities page;
http://careers.ucalgary.ca/ Job Opening ID #19142

This position is part of the AUPE bargaining unit, and falls under the Technical Job Family, Phase II. (Salary range $31.81 - $46.05/hour)
To find out more about management and staff opportunities at the University of Calgary and all we have to offer, view our Management and Staff Careers website. For more information about the Cumming School of Medicine visit Careers in the Cumming School of Medicine
Business address: 2500 University Dr NW, Calgary AB T2N 1N4
Contact information: hrhire @ ucalgary.ca

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here.